of the Bacillus Calmette Guerin vaccination on clinical symptoms of
Khalil Ansarin1, Leyla Sahebi2
and Safar Farajnia3
Disease Section, Tuberculosis and Lung Disease Research Center, Tabriz,
Islamic Republic of Iran, 2Moleculatr Biology Lab, Tuberculosis and
Lung Disease Research Center, Tabriz, Islamic Republic of Iran,
3Moleculatr Biology Lab, Tuberculosis and Lung Disease Research Center,
Tabriz, Islamic Republic of Iran
effect of previous Bacillus
Calmette Guerin (BCG) vaccination the clinical presentation
and severity of symptoms of pulmonary tuberculosis (PTb) has not been
investigated previously. The aim of this study was to explore the
effectiveness of BCG vaccination on clinical symptoms of PTb in
patients with tuberculosis from northwestern provinces of Iran.
cross sectional study on 358 patients with diagnosis of PTb was
performed recording and scoring severity of their 10 symptoms,
including cough, sputum production, hemoptysis, fever, fatigue,
weakness, loss of appetite, weight loss, dyspnea and chest pain. Also
Tb- drug resistance was tested using standard proportion method. BCG
scar and clinical symptoms were examined and recorded by clinical
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of huge mediastinal teratomas
the subjects included in study 264 cases (73. 7%) had no BCG
vaccination scar. Comparison of severity of clinical symptoms of PTB in
patients with BCG vaccine history with those lacking vaccination
history revealed the lower symptom severity in patients with history of
vaccination (vaccine effectiveness = 95.5%; p<0.00001).
Conclusion: The results of this study may imply that BCG
vaccination may decrease the severity of clinical symptoms in patients
with pulmonary tuberculosis.
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