between risk factors for lung cancer and tumor size
Antequera1, Miguel Arias-Guillen1, Francisco Rodríguez
Jerez1, Gemma Rubinos Cuadrado1, Pablo Martínez Camblor2,
Juan Bautista García Casas3 and Pere Casán Clara4
INS-HUCA, Oviedo, Asturias, Spain, 2Statistical Department, Universidad
de Oviedo, Oviedo, Asturias, Spain, 3Epidemiology Department, Facultad
de Medicina. Universidad de Oviedo, Oviedo, Asturias, Spain,
4Pneumology, INS-HUCA.Facultad de Medicina. Universidad de Oviedo,
Oviedo, Asturias, Spain
probability of developing lung cancer (LC) can be predicted from
mathematical models to assess risk factors. Our hypothesis is that
these factors could be related with tumor size.
Describe characteristics of a population with LC and assess the
relationship between risk factors and tumor size.
Retrospective study in which were included patients diagnosed with LC
in our hospital for a year. Medical history and radiology information
was collected. The volume of the tumor size was calculated from the
three diameters of the tumor.
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primary pulmonary tumors
patients patients were included, 112(80 %) men. Age 66 (10) years. BMI
27(4). Smoking history in 192 (91%), 93 (44 %) were current smokers.
Smoking intensity:52(23) packs cigarettes-year. 45 (21%) had a high
risk profession. COPD 80 (38%), radiology emphysema 43 (20 %). Personal
history of cancer in 45 (21%) and family history of LC in 21 (10%).The
most common symptoms were: pain (24%), dyspnea (20 %). Were incidental
findings 22% of cases. Tumor types: non-small 83 % (46 % adeno). Tumor
stage: III-IV 72%. Tumoral volume:77184(173402)mm3.
Tumor size was directly related to female sex (p<0.001), absence
of comorbidity and the presence of general syndrome (p<0.05) and
inversely related to the existence of COPD (p<0.05) and history
of other malignancies (p<0.05). The relationship with smoking
was expressed as “U”, small and large tumors occur
in patients who smoke more, and medium tumors in fewer smokers
Tumor size seems to be more related with social and health situation
than risk factors. Tobacco has a relationship with the size, probably
influenced by the increased monitoring of patients with other
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