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Effects of switching inhaled medication from twice a day to once a day in patients with bronchial asthma

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Naoto Watanabe1 and Sohei Makino1
1Tokyo Allergy and Respiratory, Disease Research Institute, Tokyo, Japan

Aim: We aimed to determine whether or not switching inhaled medication from twice a day to once a day would improve adherence and symptoms in patients with bronchial asthma.

Participants: Forty one patients (average age 48.7 years; 22 males, 19 females) with bronchial asthma who were prescribed with twice-daily combination drugs of inhaled corticosteroid (ICS)/long-acting beta-2 agonist (LABA)

Methods: The twice-daily regimen was changed to a regimen comprising once-daily inhalation of fluticasone furoate (FF)/vilanterol (VI), and the effects were evaluated using the Adherence Starts with Knowledge-20 (ASK-20) and a questionnaire survey of FF/VI.

Results: Among the 41 patients, 54% and 46% of them felt that the switch improved or did not change their symptoms, respectively.

One patient described palpitations as a side effect, and 30 (73%) patients responded that FF/VI was easy to inhale but 3 (7%) patients felt it was difficult to inhale.

Twenty one (51%), 2 (5%) and 8 (44%) patients inhaled the medication during the morning, midday and night, respectively.

The rate of patients who sometimes forgot to use their medication fell to 17% according to scores of ≥ 4 points in response to question 1 of the ASK-20.

Twenty four (80%) and 5 (17%) of 30 patients who scored ≥ 4 points in question 13 inhaled the same amount and more medication as before, respectively. The symptoms of 16 (53%) patients concurrently improved with better adherence.

Conclusions: Switching from ICS/LABA to FF/VI improved symptoms and adherence in about 50% of the patients.

Medication taken once a day can improve adherence in patients with bronchial asthma who feel that inhaling medication twice a day is inconvenient.

Source :
Image :

PDPI Surakarta. 10/11/17.

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